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Williams, David

One or more keywords matched the following properties of Williams, David

Property	Value
fax	312-942-2808

One or more keywords matched the following items that are connected to Williams, David

Item Type	Name
Concept	Aluminum Hydroxide
Concept	Adaptor Proteins, Signal Transducing
Concept	Immunoglobulin A
Concept	DEAD-box RNA Helicases
Concept	Parasitic Sensitivity Tests
Concept	Antiparasitic Agents
Concept	Vero Cells
Concept	Interleukin 1 Receptor Antagonist Protein
Concept	NADP
Concept	Cytokines
Concept	Filaricides
Concept	Neutrophils
Concept	Disease Models, Animal
Concept	Interleukin-10
Concept	Parasite Egg Count
Concept	Temperature
Concept	Selenium
Concept	Transforming Growth Factor beta
Concept	Ancylostoma
Concept	NF-kappa B
Concept	Interferon-gamma
Concept	Cattle
Concept	Schistosomicides
Concept	Fungal Polysaccharides
Concept	Escherichia coli
Concept	Androstadienes
Concept	Flow Cytometry
Concept	Transcription Factor RelB
Concept	Introns
Concept	HeLa Cells
Concept	Drug Discovery
Concept	Staphylococcal Infections
Concept	Interleukin-13
Concept	Deoxyribonucleases, Type II Site-Specific
Concept	Antigens, Differentiation
Concept	Drug Repositioning
Concept	Drug Design
Concept	Microfilariae
Concept	Antiprotozoal Agents
Concept	Gene Expression
Concept	Drosophila melanogaster
Concept	Macrophage Activation
Concept	Intercellular Adhesion Molecule-1
Concept	Chromones
Concept	Peptidyl Transferases
Concept	Glucosephosphate Dehydrogenase Deficiency
Concept	Immunophenotyping
Concept	Open Reading Frames
Concept	Geranyltranstransferase
Concept	Dendritic Cells
Concept	Interferons
Concept	Amino Acid Sequence
Concept	Erythrocytes
Concept	Disease Susceptibility
Concept	Myeloid Differentiation Factor 88
Concept	Retroelements
Concept	Respiratory Burst
Concept	Cell Wall
Concept	Antibodies, Neutralizing
Concept	Expressed Sequence Tags
Concept	Catalytic Domain
Concept	Myocardial Reperfusion Injury
Concept	Aorta
Concept	Interleukin-17
Concept	Proto-Oncogene Proteins c-raf
Concept	Cell Membrane
Concept	Crystallography, X-Ray
Concept	Cluster Analysis
Concept	Interleukin-1beta
Concept	Gold
Concept	Onchocerca volvulus
Concept	Lymphocyte Activation
Concept	Antioxidants
Concept	Antimalarials
Concept	Oxidation-Reduction
Concept	Leukocytes, Mononuclear
Concept	Pseudomonas aeruginosa
Concept	DNA Probes
Concept	Administration, Oral
Concept	RNA Interference
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Chromosomes, Bacterial
Concept	Fluorescent Dyes
Concept	Caenorhabditis elegans
Concept	Vitamin K 3
Concept	Cell Adhesion Molecules
Concept	Disulfides
Concept	rho GTP-Binding Proteins
Concept	Blood
Concept	DNA, Complementary
Concept	Selenocysteine
Concept	Antineoplastic Agents
Concept	Cytochrome P-450 Enzyme System
Concept	Lipid Peroxidation
Concept	Culture Media
Concept	Biological Products
Concept	Precipitin Tests
Concept	Hydrogen Peroxide
Concept	Blotting, Western
Concept	Brugia malayi
Concept	Interleukin-4
Concept	Carbohydrate Sequence
Concept	Microbial Sensitivity Tests
Concept	Flavin-Adenine Dinucleotide
Concept	CD4-Positive T-Lymphocytes
Concept	Sequence Homology, Amino Acid
Concept	I-kappa B Proteins
Concept	Dithionitrobenzoic Acid
Concept	Staining and Labeling
Concept	Aminoacyltransferases
Concept	In Situ Hybridization
Concept	Immunization
Concept	Parasitology
Concept	Macrophage Colony-Stimulating Factor
Concept	Proteomics
Concept	Th2 Cells
Concept	Cell Line
Concept	B-Lymphocytes
Concept	Carbohydrate Conformation
Concept	Myocardial Infarction
Concept	Genes, Helminth
Concept	T-Lymphocyte Subsets
Concept	Intestinal Absorption
Concept	Area Under Curve
Concept	Energy Metabolism
Concept	Chromatography, Gel
Concept	Interleukin-5
Concept	Disease Resistance
Concept	Auranofin
Concept	Cysteine
Concept	Aspergillus fumigatus
Concept	Serum
Concept	Drug Evaluation, Preclinical
Concept	Electrons
Concept	Transcription, Genetic
Concept	Chromosomes, Artificial, Bacterial
Concept	Leukocytes
Concept	Tumor Necrosis Factor-alpha
Concept	Limulus Test
Concept	Loa
Concept	In Situ Hybridization, Fluorescence
Concept	U937 Cells
Concept	Anthelmintics
Concept	Chemokines
Concept	Glutathione S-Transferase pi
Concept	Base Sequence
Concept	Amino Acid Motifs
Concept	Zebrafish
Concept	Interferon Type I
Concept	Genes, Homeobox
Concept	Immunohistochemistry
Concept	Injections, Intravenous
Concept	Actin Cytoskeleton
Concept	Cell Line, Tumor
Concept	Molecular Sequence Data
Concept	Albendazole
Concept	Immune Sera
Concept	Exons
Concept	Vibrio
Concept	Lectins, C-Type
Concept	Toll-Like Receptor 2
Concept	Computational Biology
Concept	Cells, Cultured
Concept	T-Lymphocytes
Concept	Coordination Complexes
Concept	Cadmium
Concept	Injections, Intraperitoneal
Concept	Monocytes
Concept	Interleukin-2
Concept	Diethylcarbamazine
Concept	Cell Count
Academic Article	Characterisation of a Rho homologue of Schistosoma mansoni.
Academic Article	Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni.
Academic Article	Murine immune responses to a novel schistosome egg antigen, SmEP25.
Academic Article	Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host.
Academic Article	Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE).
Academic Article	Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.
Academic Article	Proteomic analysis of Schistosoma mansoni egg secretions.
Academic Article	Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.
Academic Article	Identification of oxadiazoles as new drug leads for the control of schistosomiasis.
Academic Article	A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.
Academic Article	Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.
Academic Article	Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation.
Academic Article	Characterization of the methionine sulfoxide reductases of Schistosoma mansoni.
Academic Article	The genome of the blood fluke Schistosoma mansoni.
Academic Article	Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.
Academic Article	Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
Academic Article	Whole mount in situ hybridization methodology for Schistosoma mansoni.
Academic Article	An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy.
Academic Article	Characterization of the phytochelatin synthase of Schistosoma mansoni.
Academic Article	Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.
Academic Article	Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.
Academic Article	On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases.
Academic Article	The redox biology of schistosome parasites and applications for drug development.
Academic Article	Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni.
Academic Article	Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.
Academic Article	Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Academic Article	Transcriptional analysis of a unique set of genes involved in Schistosoma mansoni female reproductive biology.
Academic Article	Towards an understanding of the function of the phytochelatin synthase of Schistosoma mansoni.
Academic Article	Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A.
Academic Article	Characterization of the phytochelatin synthase from the human parasitic nematode Ancylostoma ceylanicum.
Academic Article	Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.
Academic Article	Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation.
Academic Article	New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.
Academic Article	Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.
Academic Article	Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs.
Academic Article	High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis.
Academic Article	The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.
Academic Article	The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase.
Academic Article	Boudicca, a retrovirus-like long terminal repeat retrotransposon from the genome of the human blood fluke Schistosoma mansoni.
Academic Article	Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets.
Academic Article	Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.
Academic Article	Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target.
Academic Article	Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.
Academic Article	Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals.
Academic Article	Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase.
Academic Article	Construction and characterization of a Schistosoma mansoni bacterial artificial chromosome library.
Academic Article	Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase.
Academic Article	Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism.
Academic Article	Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner.
Academic Article	Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.
Academic Article	Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics.
Academic Article	Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.
Academic Article	Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
Academic Article	Ectopic suicide inhibition of thioredoxin glutathione reductase.
Academic Article	Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis.
Academic Article	Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections.
Academic Article	Taking Advantage of the Morpheein Behavior of Peroxiredoxin in Bionanotechnology.
Academic Article	Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Academic Article	Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.
Academic Article	Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.
Academic Article	Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast.
Academic Article	Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.
Academic Article	Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors.
Academic Article	C. albicans increases cell wall mannoprotein, but not mannan, in response to blood, serum and cultivation at physiological temperature.
Academic Article	Soluble Dectin-1 as a tool to detect beta-glucans.
Academic Article	Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata.
Academic Article	Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature.
Academic Article	An anti-inflammatory property of Candida albicans ?-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism.
Academic Article	New insights into the structure of (1?3,1?6)-?-D-glucan side chains in the Candida glabrata cell wall.
Academic Article	Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.
Academic Article	Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
Academic Article	?-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages.
Academic Article	Glucan and glycogen exist as a covalently linked macromolecular complex in the cell wall of Candida albicans and other Candida species.
Academic Article	Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function.
Academic Article	Dendritic cell interaction with Candida albicans critically depends on N-linked mannan.
Academic Article	The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis.
Academic Article	Innate Immune Memory and the Host Response to Infection.
Academic Article	Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans.
Academic Article	An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Academic Article	Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.
Academic Article	Cellular and molecular mechanisms of fungal ?-(1?6)-glucan in macrophages.
Academic Article	Internalization of Dectin-1 terminates induction of inflammatory responses.
Academic Article	4-Acetoxy-2,2-dimethylbutanoate: a useful carbohydrate protecting group for the selective formation of ?-(1?3)-d-glucans.
Academic Article	Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties.
Academic Article	Impaired phagocytosis directs human monocyte activation in response to fungal derived ?-glucan particles.
Academic Article	Dectin-1 mediates the biological effects of beta-glucans.
Academic Article	Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.
Academic Article	Structural characterization of (1-->3)-beta-D-glucans isolated from blastospore and hyphal forms of Candida albicans.
Academic Article	The macrophage mannose receptor induces IL-17 in response to Candida albicans.
Academic Article	Beta-glucan's varying structure characteristics modulate survival and immune-related genes expression from Vibrio harveyi-infected Artemia franciscana in gnotobiotic conditions.
Academic Article	Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway.
Academic Article	Identification of (1-->6)-beta-D-glucan as the major carbohydrate component of the Malassezia sympodialis cell wall.
Academic Article	Engineering Nanogels for Drug Delivery to Pathogenic Fungi Aspergillus fumigatus by Tuning Polymer Amphiphilicity.
Academic Article	The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans.
Academic Article	Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats.
Academic Article	Mannan Molecular Substructures Control Nanoscale Glucan Exposure in Candida.
Academic Article	Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris.
Academic Article	Candida albicans ?-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages.
Academic Article	Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
Academic Article	Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo.
Academic Article	Glycogen Metabolism in Candida albicans Impacts Fitness and Virulence during Vulvovaginal and Invasive Candidiasis.
Academic Article	Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni.
Academic Article	Isolation, Physicochemical Characterization, Labeling, and Biological Evaluation of Mannans and Glucans.
Concept	NLR Family, Pyrin Domain-Containing 3 Protein

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